关键词:

朊病毒病,

朊蛋白,

基因治疗,

免疫治疗

Abstract:

Prions are infectious proteins formed by normal prion proteins in vivo， and prion diseases are a class of fatal neurodegenerative diseases triggered by prions. At present， although there is no clinical method to treat prion disease， a large number of researchers have studied from many angles and made some progress. This article provided a brief illustration of recent prion disease treatment options related to traditional chemical drugs， gene therapy， immunotherapy and homologous prion proteins， with an emphasis on novel drugs that target intracellular signaling pathways as well as intracellular signaling pathways of mitochondria associated with prion proteins with potential utility. This paper aimed to provide a theoretical basis for the new research direction of prion， in order to promote the clinical application of prion treatment methods.

Key words:

prion disease,

prion proteins,

signaling pathway,

gene therapy,

immunotherapy